Endocrine Abstracts

A 63-year old woman presented with a 3 weeks history of sweating, panic attacks and vomiting. Urine dipstick on admission was positive for glucose (3+) and ketones (2+) and lab glucose was elevated at 26 mmol/l. Based on the findings she was treated as diabetic ketoacidosis and commenced on insulin. Further investigations showed an elevated urinary catecholamines and marked hypercalcaemia (adjusted calcium 3.10 mmol/l) with unsuppressed PTH at 71 pg/ml (normal 12–72 pg/ml...

Background: Women with polycystic ovarian syndrome (PCOS) tend to have a cluster of several coronary risk factors, including atherogenic dyslipidaemia. Metformin has been used to improve their hyperandrogenism and to induce ovulation. However, its effects on hyperlipidaemia are less clear and it is not known if metformin also ameliorates lipid intrinsic variability.Aim: The primary end point of the study was to evaluate the effects of metformin and a hyp...

ObjectiveIn polycystic ovarian syndrome (PCOS), C-reactive protein (CRP) concentration is elevated and inversely related to insulin sensitivity. However, no data exists on the biological variability of CRP in PCOS.MethodsBlood samples were collected after an overnight fast at four-day intervals on 10 consecutive occasions from 12 patients with PCOS and 11 weight and age matched Caucasian women (controls). Dup...

There has been controversy over the diagnostic utility of the LH/FSH ratio in polycystic ovarian syndrome, with more recent guidelines excluding it as a diagnostic test. However, LH/FSH is still often requested for that purpose and in our institution, 20% of the 12,000 annual requests for LH/FSH tests requested in a one year period had PCOS detailed on the card, at a cost of over £37,000.Objective: The aim of this study was to ascertain the biologi...

Introduction: Abdominal obesity and insulin resistance are risk factors for erectile dysfunction (ED). ED is associated with hypoandrogenism, endothelial dysfunction, lower urinary tract symptoms (LUTS), and reduced quality of life (QoL). We aimed to compare effects of lifestyle modification-induced weight loss on insulin resistance, endothelial and sexual function, LUTS and QoL in obese non-diabetic men with and without ED.Methods: Seventy abdominally o...

Introduction: Androgen deficiency (AD) is associated with endothelial and erectile dysfunction, lower urinary tract symptoms (LUTS) and reduced quality of life (QoL) in obesity. We aimed to compare effects of weight loss induced by lifestyle modification on endothelial and erectile function, LUTS and QoL in obese men with and without AD.Methods: abdominally obese Asian (body mass index≥30 kg/m2, waist circumference [WC] ≧ 90 cm) m...